Karnes City is a city in and county seat of Karnes County, Texas, United States. The population was 3,111 at the 2020 census, up from 3,042 at the 2010 census. The town was named after Henry Karnes of the Texas Revolution. Karnes is 24 miles (39 km) southeast of Floresville and 54 miles (87 km) southeast of San Antonio on U.S. Highway 181.
Zip Codes in Karnes City, TX that we also serve: 78118
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